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INTRODUCTION While lifestyle changes such as dietary modification and increased physical activity can be very effective in improving glycemic control, over the long-term most individuals with Type 2 diabetes (T2DM ) will require medications to achieve and maintain glycemic control (1)

Although ROS production correlates with bile acid concentration, clinically significant injury remains largely idiosyncratic and amplified in genetically susceptible individuals (e.g., SLCO1B1 variants)

The demand for more convenient and effective treatment options has spurred innovation in both injectable and oral therapies, including insulin analogs and newer drug classes such as SGLT-2 inhibitors and GLP-1 receptor agonists

What sets GLP-1 medications apart from previous generations of weight loss drugs is the breadth and depth of their mechanism