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Its downstream signaling through PI3K/Akt/mTOR and MAPK/ERK makes it relevant to a wide range of research questions in muscle biology, bone physiology, neuroprotection, and metabolic signaling

Malnutrition in cirrhotic patients is characterized by the loss of skeletal muscle and lean body mass (sarcopenia), adipose (fat) tissue (adipopenia), or both (hepatic cachexia), and does not respond to adequate dietary intake of fats or protein

For example, depletion of striatal DA via the neurotoxin 6-hydroxy-dopamine in rats produces aphagia and akinesia

Beyond prescription medications, some dietary supplements contain amino acid blends or collagen peptides marketed for metabolism, though these are not equivalent to pharmaceutical peptides