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In murine models of diet-induced MASH, loss of CD8 + T cell-derived perforin exacerbates liver injury and promotes the expansion of proinflammatory monocytes and overactivation of hepatic CD8 + T cells (143)
GPx1 catalyzes the neutralization of hydrogen peroxide and organic peroxides and thus protects cells from oxidative stress
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Next, we will summarize some promising medicine monomers that activate the GSH system based on the categories of natural medicines, including flavonoids, terpenoids, phenolic acids, quinones, and alkaloids (Table 2, Supplementary Table S2)
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