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10.3390/antiox11020318 8 BonanomiL.GazzanigaA

www.medcram.com Oxidative stress causes disease and the mechanisms for reducing it Starting from the left and working right This diagram shows how oxygen (O2) can be oxidized to two forms of Reactive Oxygen Species (ROS), the dangerous Superoxide Radical O2 .and then further right into an equally dangerous Hydroxy Radical (OH )

Figure 1 2.1 Overproduction of ROS One hallmark feature of IBD is the overproduction of ROS, which causes dysregulation of signal transduction, an inflammatory response, and DNA damage, all of which contribute to the progression and deterioration of the disease ( 2), nitric oxide (NO), hydroxyl radical (-0H), hydroperoxyl radical (O 2 H), hydrogen peroxide (H 2 O 2 ), and singlet oxygen ( 2.2 Damage to biomolecules ROS can damage various cell biomolecules, including lipids, proteins, and DNA