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Tea and coffee polyphenols, including theaflavins and chlorogenic acid derivatives, also inhibit DNMT3a at physiologically relevant concentrations

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They are not recommended for long-term use and are typically replaced with 5-ASA drugs once remission has been induced

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Similar findings were seen with once-weekly, subcutaneous tirzepatide (5 mg, 10 mg, or 15 mg) [27], demonstrating the utility of GLP-1RAs for obesity management

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