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Under stress conditions, BiP is released and thus activates the IRE-1, ATF6, and PERK signaling cascades.58 ER stress plays a role in the occurrence and development of diabetes and IR in peripheral tissues such as the pancreas, liver, adipose tissues, and skeletal muscle.5863 Although some of the effects of ER stress are tissue-specific, there are some commonalities in the damage to insulin signaling
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Abstract Nuclear factor erythroid 2-related factor 2 (NRF2) is a key transcription factor involved in regulating cellular antioxidant defense and detoxification mechanisms
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