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Within the non-student demographic, the group receiving the supplement demonstrated a statistically significant decline in Hamilton Rating Scale for Depression (HAM-D) scores, achieving a reduction of 10 points at 3 weeks and 12 points at 6 weeks, alongside enhanced remission rates and superior improvements in both anxiety and depression metrics compared to the placebo group

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To prevent any negative effect on sleep, it may be advisable not to take a vitamin B12 supplement at the end of the day

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