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They have been shown to enhance the expression of the amyloid precursor protein (APP) processing enzyme beta-site APP cleaving enzyme 1 (BACE), thereby promoting A accumulation in patients with AD and various mouse models 54

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This is why GLP-1 and microbiome research often focuses on how microbial fermentation, gut barrier stability, and enteroendocrine signaling work together before hormone release occurs

In controls a basal expression of GFAP is indeed observed, but this is topographically limited to the inner retinal layer (Figure 1a, 1) both in controls and in animals not subjected to the hypertensive shock but simply treated with carnitine (not shown)