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After its made in the skin as vitamin D3 (cholecalciferol), it becomes converted by the liver and kidney into a secosteroid hormone (calcitriol) that has receptors in practically all our tissues

Newer oral forms, liposomal ones for instance, absorb better, but intravenous delivery still offers the highest bioavailability, because practically the whole dose reaches the blood

1 Moreover, despite that fact that APAP can cross the placental barrier, the only instances when the fetus has been shown to be at risk is when the mother suffers from severe APAP hepatotoxicity, which is usually apparent based on the history of presenting illness

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