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The GLP-1RA cohort compared with the SGLT2 cohort included more women, more Black people, had higher SDOHs and prevalence of thyroid disorders, kidney disease, and prior prescriptions of opioids, diuretics, antihistamines, and antidepressants

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Preclinical models found that GLP-1 RAs reduce intestinal inflammation in dextran sulfate sodium (DSS)-induced colitis, by increasing IL-22 production by colonic IELs and several beneficial bacteria, including Firmicutes, Proteobacteria and Lactobacillus reuteri (93)