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For pathway enrichment analysis of the reversed DEGs of a given cell type using the v3 kit-based dataset, DEGs with fold changes ranking within top 500 in both age-stratified and treatment-stratified comparisons and opposite directionality of changes were included (i.e., top reversed DEGs)

This shows that while gastrointestinal issues are common, most patients are able to continue treatment successfully with dose adjustments or supportive care