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Mean concentrations were calculated for a 10-minutes baseline period before each stimulation/inhibition and for the last 10 min of each stimulation/inhibition period

This Gs-biased profile may contribute to sustained receptor signaling with less desensitization, though the clinical implications of signaling bias in GLP-1 therapeutics remain an area of active investigation

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Thus, the trend of finding less invasive and more natural methods of managing leiomyoma appears to be very important in the era of postponement of patients procreation plans and the growing problem of infertility