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Trust the process: Consistent use over several months leads to the best long-term results

Subjects were instructed to complete as many repetitions as possible until momentary muscular failure was reached, which was defined as a) volitional muscle failure or b) failure to complete two successive repetitions at the prescribed metronome cadence

When interpreted together with the findings of the STEP 4 withdrawal trial and STEP 1 off-treatment extension study, which both showed weight regain after semaglutide discontinuation (after 20 weeks treatment in STEP 4 and 68 weeks treatment in STEP 1) 23,24 , these results support the benefit of continued semaglutide treatment for sustained weight loss