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A landmark observational study found that glutathione deficiency (measured as low cysteine levels) was an independent predictor of 2-year survival in HIV patients [38]

Antioxidants act as protective agents by counteracting this oxidative damage and reducing the risk of cancer

Furthermore, as activated immune cells, melanophages may communicate and stimulate dermal T lymphocytes and secrete proinflammatory cytokines, potentially sustaining the chronic status of the hyperpigmented lesion [157, 158]