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Treatment of HCC cells with ADI-PEG20 downregulates the key enzymes of pyrimidine synthesis in the TCA cycle, carbamoyl phosphate synthetase 2, thymine synthase (TS), aspartate transcarbamylase and dihydrooratase (CAD) and malate dehydrogenase 1 (MDH-1) activities, making tumor cells more susceptible to 5-fluorouracil (5-FU)

GLP-1 binds to its receptors which are expressed on various cells throughout the body

Clinical trials ranging from 3 weeks to 16 weeks have consistently shown that eating 3090g of macadamia nuts daily either reduces body weight or has zero effect on it - while improving cholesterol profiles, lowering inflammatory markers, and stabilising blood sugar

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