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found that a one-week course of combined broad-spectrum antibiotics (ciprofloxacin, vancomycin, and metronidazole) has a profound and long-lasting impact on the gut microbiota of healthy humans, causing loss of diversity and shifts in community composition

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For Canadian researchers, the choice depends on whether the research question specifically engages inflammation biology in ways that KPV's mechanism addresses, or whether the three GLOW mechanisms adequately cover the research scope