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The STEP pooled analysis showed weight loss was roughly the same whether patients had GI symptoms or not

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR 999077, China 6

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(102) demonstrated that pretreatment with Ex-4 for a week, induced tolerance to cerebral ischemia that lasted for at least 6 days in the mouse brain after MCAO and this neuroprotective state was related to upregulation of IGF-1R which was mediated by GLP-1R and, following by activation of the IGF1R-regulated the PI3K/AKT/mTOR/HIF-1 pathway by binding to IGF-1