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Conclusions Evidence accrued so far suggest that GLP-1RA could exert a modest renal benefit alongside CV protection, justifying its place as second-line drug in patients with T2D and CKD not achieving glycemic control with SGLT-2i and metformin according to KDIGO guidelines [87]

As the body adapts to tirzepatide's effects on gastric emptying and central appetite regulation, these symptoms typically diminish in both frequency and severity

For young adults and older patients alike, ensuring adequate B12 levels can enhance their overall well-being while managing weight and blood sugar effectively

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