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Diffuse collagen loss and reduced skin thickness across the face respond best to growth hormone-stimulating peptides (CJC-1295/Ipamorelin or Tesamorelin)
Metabolic approaches: GLP-1 Incretins (semaglutide): appetite suppression | GLP-1/GIP incretins (tirzepatide): dual hormonal agonism | 5-Amino-1MQ: NNMT enzyme inhibition a non-hormonal mechanism, directly targeting lipid and NAD+ metabolism
Research Focus
NAD+, a compound naturally found in every cell, plays a central role in these processes by helping convert nutrients into usable energy and supporting cell repair systems
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