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Obesity is a well-established risk factor for lymphedema development and progression, particularly in cancer survivors, as documented in NCCN Survivorship Guidelines and National Lymphedema Network position papers
The strong metal binding affinity of the imidazole ring on the histidine side chain brings oxidizing species close to the substrate methionine (6)
Rather than counteracting with any other brightening components (were talking vitamin C, licorice or azelaic acid), this iconic ingredient actually enhances the performance of other antioxidants
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