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Our analysis showed that the number of cardiovascular events prevented increased linearly with higher oral semaglutide uptake, reflecting the proportional relationship between treatment coverage and population-level benefit
This impacts product positioning and supply chain strategies
The authors suggest that this might be because SELECT was designed as a cardiovascular outcomes trial and not a weight-loss trial so those in STEP 1 were desirous of weight loss as a reason for study participation and/or because they received structured lifestyle intervention (which included a 500 kcal per day diet with 150 min per week of physical activity)
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