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He argues that sponsors should be challenging carriers now on their strategy for upcoming generics and ultra generics - including how they will use tools such as price listing agreements, plan design, tiered formularies, maximum allowable cost and step therapy - and making sure those strategies are explicitly designed so that savings are captured quickly and flow directly back to the plan

Outside of bariatric surgery, no treatment had ever produced numbers like that

If patients experience intolerable side effects at a given dose, maintaining the current dose for an additional 4 weeks or temporarily reducing the dose may improve tolerance before attempting further escalation