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The goal for most adults on GLP-1 medications is at least 80-100 ounces of fluid daily, more in hot weather or if you exercise

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Instruct patients to contact their healthcare provider if they have severe or persistent gastrointestinal symptoms [see Warnings and Precautions (5.6)]

Possible Side Effects Observed in Research Settings Semaglutide has been explored in laboratory and experimental research settings, and observed responses in some research contexts have included: Nausea Gastrointestinal discomfort Reduced appetite-related observations Vomiting Diarrhea or constipation Bloating or abdominal discomfort Fatigue or lethargy Headaches Injection-site irritation or redness Gastrointestinal & Administration Considerations In some research models, more significant gastrointestinal-related observations have been reported during higher-exposure or administration-escalation protocols