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Weight gain is caused in part by fluid retention, and may also result from PPAR-gamma activation that results in increased adipose tissue mass, and a central effect to increase feeding (McCulloch, 2015) Notes: these drugs are also euglycemics Black Box Warning: CONGESTIVE HEART FAILURE HEART FAILURE: Thiazolidinediones, including rosiglitazone cause or exacerbate CHF in some patients

GLP-1 medications are not recommended for anyone with a personal or family history of medullary thyroid cancer or MEN syndrome type 2, and they should be used cautiously in those with a history of pancreatitis

doi: 10.1210/jendso/bvab048

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