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This event is followed by the generation of ROS from the oxidation of FADH2 as induced by the demethylase, with consequent oxidation of nearby guanines (8-oxo-Gs) and recruitment of DNA repair enzymes (among which is APE1) that cause single-strand breaks in DNA and enable looping between the enhencer/promoter and the polyadenylation sites of the target genes, with productive transcription 140,141

Acknowledgments Research reported in this article was supported by grants from the National Institutes of Health R01AI107022 and RO1AI083986 (HH), R01AI113162 and R01AI130103 (FF), and a fund provided by Sun Yet-Sen University (JL)

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Cortisol is catabolic and directly antagonizes growth hormone's anabolic effects