Exposure to cold temperatures activates production of proteins including RNA-binding motif protein 3 (RBM3), which demonstrates neuroprotective effects and may help maintain muscle mass during periods of reduced activity
Birkisdttir MB, Jaarsma D, Brandt RM, Barnhoorn S, van Vliet N, Imholz S, van Oostrom CT, Nagarajah B, Portilla Fernndez E, Roks AJ, Elgersma Y (2021) Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice
Thioredoxin-interacting protein deficiency protects against severe acute pancreatitis by suppressing apoptosis signal-regulating kinase 1
In addition to the role played by NO in muscular atrophy, experiments with NOS inhibitors have also demonstrated a reduction of muscle hypertrophy in association with an increase in slow myosin heavy chains and -actin expression [133,134,135]