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Nature 631 , 654662 (2024)

In addition, SGLT-2 inhibitors have shown benefit in patients with both HFrEF and HFpEF independently of diabetes status, which opens exciting possibilities for the use of these therapies in patients at risk for or with established CV or kidney disease without T2D

Overall, Mg 2+ is well-tolerated although there are some dose-dependent side effects such as nausea, diarrhea, stomachache, headache, tinnitus, and dizziness, which appear when used at high concentrations (Attias et al., 1994

This study shows some beneficial anti-inflammatory effects of metformin in humans, irrespective of their diabetic status