This combination activates lethal autophagy dependent on AMPK activation (AMPK kinase is activated by a decrease in intracellular ATP and a change in the ATP:AMP ratio), enhancing the sensitivity of radiation-resistant cells to cell death and efficacy of radiotherapy 29,77 (Figure 3)
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B.S., M.S.-R., P.V.T.F., N.M., and J.S.-R., critically reviewed the manuscript