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Same day is simpler, but some users split them - tirzepatide Monday and cagrilintide Thursday - to spread out GI side effects during titration

10.1038/nrendo.2018.24 Nat Rev Endocrinol

A review study proposed another mechanisms underlying the potential interaction of the smoking and oestrogen metabolites such as decrease in oestrogen activity, SHBG levels, aromatase enzyme activity, C-20, 22 desmolase enzyme levels and increase in free testosterone levels, hyperandrogenism and the hepatic metabolism of steroid (Reference Ruan and Mueck41)