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For a comprehensive review of these mechanisms, a peer-reviewed study in Cell and Tissue Research documenting the role of gastric pentadecapeptide BPC-157 in accelerating musculoskeletal soft tissue healing lays out the signaling cascade in detail

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Desensitization occurs through rearrangement of the dimer interface, which disengages the agonist-induced conformational change in the ligand-binding core from the ion channel gate