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Cant C, et al

NNMT inhibitors are selective and do not impact related methyltransferases or enzymes in the NAD + salvage pathway The selectivity of NNMT inhibitors was confirmed by testing against a panel of structurally similar methyltransferases and two enzymes in the NAD + salvage pathway (NAMPT and SIRT1

The graph shows that in 2022, more than 5 million prescriptions for obesity drugs were written for weight loss compared with just over 230,000 in 2019