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Each acts through distinct mechanisms, from tight junction restoration and NF-B inhibition to mitochondrial AMPK activation
Muller, T.D., et al., Glucagon-like peptide 1 (GLP-1)
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For example, different actions of GLP-1 receptor agonists such as delaying gastric emptying which leads to a prolonged feeling of fullness and reducing food intake lead to significant weight loss ( Endogenous GLP-1 has a short half-life since it is in 1-2 minutes degraded by the enzyme dipeptidyl peptidase-4 (DPP-4)
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