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How to Taper Off GLP-1 Medications: Stopping, Switching, and Preventing Weight Regain At a glance Weight regain risk / ~two-thirds of lost weight returns within 1 year of abrupt discontinuation (STEP-1 extension) Semaglutide 2.4 mg peak loss / 14.9% mean body weight at 68 weeks (STEP-1, N=1,961) Tirzepatide 15 mg peak loss / up to 20.9% mean body weight at 72 weeks (SURMOUNT-1, N=2,539) SURMOUNT-4 maintenance finding / continuing tirzepatide vs