However, FOXO4-DRI treatment significantly reduced the expression of these detrimental SASP factors and, critically, restored the proliferation of GC-1 spg cells in the co-culture system, as evidenced by CCK-8 assays and PCNA expression, without inducing apoptosis in the spermatogonia
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Natural killer cytotoxicity - the ability of NK cells to kill target cells such as those infected by viruses - also increased by more than two-fold compared to placebo
Matsuzawa, N