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Here in the UK, a B12 deficiency would usually mean 6 injections aver the course of a month (loading doses) then 1 every 3 months (maintenance doses)- a regime that seems dissatisfactory to the point of detriment to many many people, but one we have been stuck with for far too long

Reuben A, Tillman H, Fontana RJ, Davern T, McGuire B, Stravitz RT, Durkalski V, Larson AM, Liou I, Fix O, Schilsky M, McCashland T, Hay JE, Murray N, Shaikh OS, Ganger D, Zaman A, Han SB, Chung RT, Smith A, Brown R, Crippin J, Harrison ME, Koch D, Munoz S, Reddy KR, Rossaro L, Satyanarayana R, Hassanein T, Hanje AJ, Olson J, Subramanian R, Karvellas C, Hameed B, Sherker AH, Robuck P, Lee WM

Neuronal inflammation was also attenuated by suppression of the HMGB1 (high mobility group box-1)/TLR4 (toll-like receptors)/NLRP3 (nod-like receptor protein) inflammasome [52]

The six peptides are not currently listed in 21 CFR 216.23, the FDA has not issued a final determination, and none became an FDA-approved drug because of the vote