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102 Effects of GLP-1RAs on Cardiovascular System Within the cardiovascular system, the GLP-1 receptor is expressed in both cardiac myocytes and endothelial cells, 103 indicating that GLP-1 receptor activation exerts both direct and indirect effects on cardiac and vascular functions

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6 Alternatively, some patients may be prescribed sulfonylureas or thiazolidiniones to improve insulin secretion, but both of these treatment options are associated with an elevated risk of heart failure making them unsuitable for use in patients with cardiovascular disease