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In the normal pancreas specimen, no -SMA-positive PSCs (activated myofibroblast-like cells) were seen, however, GFAP-positive quiescent PSCs showed low expression of the GLP-1R (Figures 1 eg)

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In vitro studies with HEK cells stably transfected with various UGT1A6 amino acid variants indicate that the UGT1A6 *2 genotype had a 60% higher glucuronidation activity than the UGT1A6*1 variant [21]

Polyphenols have the potential to suppress the development of cancer cells through various mechanisms, including interfering with the signaling of growth factor receptors and the cell cycle progression, modulating phosphodiesterase, promoting cellular differentiation and cyclooxygenase pathways, and inhibiting cell signaling kinases