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5 Potential pathophysiological mechanisms of toll-like receptors and gut bacterial translocation in schizophrenia and psychiatric disorders Toll-like receptors (TLRs) coordinate the activation of innate immune responses alongside the complement system and play a significant role in the neuroimmune mechanisms of schizophrenia

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By binding to copper at the active site of tyrosinase and interfering with melanin synthesis intermediates, glutathione reduces overall melanin formation. As a powerful antioxidant, glutathione also reduces free radicalinduced oxidative stress, which is one of the triggers for increased tyrosinase activity and melanin production