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However, limitations exist in the form of in vivo instability, the reliance on carriers that are biocompatible and robust and limited sites of application (local and direct) (Park et al

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A second argument in favour of direct stimulation of upper-gut L-cells is the observation that the release of GIP is closely related to that of GLP-1, even at an intra-individual level, indicating that some individuals have a poor response of GIP and GLP-1, and others have average or higher release of both incretin hormones [20]