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Under hypoxic conditions, the mitochondrial Ala-tRNA synthetase AARS2 catalyzes lactylation of PDHA1 at lysine 336, blocking pyruvate entry into oxidative phosphorylation and redirecting carbon flux toward glycolysis, thereby accelerating the Warburg metabolic program [55]

[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Sheyn, U., Rosenwasser, S., Ben-Dor, S., Porat, Z

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