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Inactivation of the prolyl isomerase Pin1 sensitizes BRCA1-proficient breast cancer to PARP inhibition

Jelinek, Khalifa University, United Arab Emirates Reviewed by Qinghe Meng, Upstate Medical University, United States Navid Abedpoor, Islamic Azad University, Iran Updates Copyright 2026 Ranasinghe, Mathai and Zulli

The mechanisms of HIF-1a involved in acute hypobaric hypoxia include the ROS pathway, the Toll-like receptor 4 (TLR4) signaling pathway, and the autophagy pathway ( With its multi-compounds and multi-target properties, traditional Chinese medicine (TCM) has been widely used as an alternative medical treatment for various diseases (Li et al., 2020b)

For patients who want to add lean tissue and reduce fat simultaneously, rather than bulk and cut in separate cycles, GH secretagogues create the hormonal environment that makes concurrent recomposition more achievable than it would be with training and nutrition alone