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This link is believed to be primarily mediated by the metabolic, vascular, and inflammatory pathways associated with diabetes, which contribute to the pathogenesis of neurodegeneration

Yuan et al., 2021)

174 Accumulated ceramide mediates the activation of protein phosphatase 2 A (PP2A) and impairs insulin-dependent activation, in addition to signaling of PI3K/Akt by PKC, 175 thereby also disrupting lipid metabolism by inhibiting oxidation and stimulating fatty acid uptake

It employs qualitative research methodologies, including unstructured interviews, exploratory and dialogic surveys, data analysis, and comparative analysis