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In line with this finding, we also found a significantly elevated GLP-1R protein level in the aorta tissues of HFD-fed ApoE / mice treated with metformin alone or in combination with liraglutide (Supplemental Fig

Activated mTOR/P70S6K signaling pathway is involved in insulinoma tumorigenesis

In HG-treated HK-2 and HFD/STZ-induced C57BL/6J mouse models, Finerenone (FIN) was found to restore mitophagy, reduce oxidative stress and apoptosis, and alleviate renal tubular injury through the PI3K/Akt/eNOS signaling pathway, thus exerting a certain therapeutic effect on DKD [139]

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