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This antitumorigenic effect is mediated through the activation of cyclin-dependent kinase inhibitors specifically p21 & p27, which disrupt the action of mitogenic growth factors such as insulin-like growth factor 1 (IGF-1) and epidermal growth factor (EGF), while simultaneously enhancing the tumour-suppressive effects of transforming growth factor-beta (TGF-)

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High-dose vitamin C improves immune response and reduces inflammation, while B vitamins support energy production and neurological function

Most supporting research comes from animal and cell studies, including tendon and ligament injury models, while large human trials have not been identified