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One aliquot was treated with 10 M compound 6a (achieved by adding 1.7 l of a 10 mM DMSO stock to 1.7 ml sample, yielding 0.1% DMSO final concentration), while the control aliquot received an equivalent volume of DMSO alone

Individuals with serum IGF-I level at or above the median value (140 g/L) had half the risk for heart failure (hazard ratio, 0.49 [95% CI, 0.26 to 0.92]) of those with serum IGF-I levels below the median