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(2025) doi: 10.1001/jamapsychiatry.2024.4789 Summary Keywords alcohol use, All of Us cohort, cocaine dependence, drug repurposing, GLP-1 receptor agonists, nicotine dependence, opioid use, substance use disorders Citation Abegaz TM, Ahmed M, Bhagavathula AS and Frietze G (2026) Association between GLP-1 receptor agonist use and substance use disorders among individuals with type 2 diabetes or obesity: a nested case-control study in the All of Us research program

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GLP-1R activation leads to a rapid increase in the levels of cyclic adenosine monophosphate (AMP) and intracellular calcium followed by glucose-dependent insulin release