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ROS are produced in mitochondria (mainly via the electron transport chain, where ~12% of O 2 is reduced to form superoxide anions), peroxisomes (through the -oxidation of fatty acids) and the endoplasmic reticulum (through the oxidation of proteins)

Ashwagandha contains other potentially beneficial bioactive compounds such as flavonoids, tannins, and amino acids that may contribute to overall health benefits

Its not fixing the underlying cause

A set of mitogen-activated protein kinase (MAPKKK, MAPKK, and MAPK) pathways can be initiated by the phosphorylation of IRS-1 and Shc, which can also result in the recruitment of Grb2, SOS, and Ras