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Remove the needle and replace the pen cap

"Semaglutide" Class GLP-1 Receptor Agonist (Glucagon-Like Peptide-1 analogue) Mechanism of Action (MOA) Mimics endogenous GLP-1 hormone Stimulates glucose-dependent insulin secretion from pancreatic -cells Suppresses glucagon release from -cells Delays gastric emptying prolonged satiety Acts on hypothalamic appetite centers reduced food intake Result: Improved glycemic control + significant weight reduction Approved Uses Type 2 Diabetes Mellitus improves glycemic control Chronic Weight Management (obesity / overweight with comorbidities) Reduction of cardiovascular risk in T2DM patients with established CVD Contraindications Personal or family history of Medullary Thyroid Carcinoma (MTC) Multiple Endocrine Neoplasia Syndrome type 2 (MEN2) Known hypersensitivity to semaglutide Caution in patients with history of pancreatitis Use in Pregnancy Not recommended during pregnancy Animal studies show potential fetal harm and weight-loss drugs are generally avoided in pregnancy

Hanzel, J

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