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doi: 10.1016/j.jacc.2016.09.972 41 KalhanSCGuoLEdmisonJDasarathySMcCulloughAJHansonRWet al

What they found (summary): Development of Melanotan II as a cutaneous drug failed due to the combination of side effects Bifurcation into more selective derivatives was both scientifically and commercially successful PT-141 Bremelanotide (Vyleesi, 2019) Melanotan I Afamelanotide (Scenesse, 2014) Underground use of Melanotan II is safety-problematic Why it matters: This is the definitive historical review by the founders of the field

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[3] Here, we will discuss several putative nootropics of interest, spanning these categories with a special focus on lesser-known, novel approaches to cognitive enhancement