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Most ephedrine/pseudoephedrine-induced manic episodes involve a pre-existing mood disorder history, suggesting that ephedrine may exacerbate pre-existing mood disorders, or precipitate a previously unproven one [101,102,103,104]

Your provider may recommend: Shorter time at the 2.5 mg initiation dose (3 weeks instead of 4) More aggressive titration to reach therapeutic levels sooner Targeting higher maintenance doses (12.5 to 15 mg) from the outset Closer monitoring of side effects to balance speed with tolerance The microdosing alternative for sensitive switchers Not everyone needs or wants to follow the standard titration

This has contributed to a significant increase in demand for and interest in GLP-1RAs around the world